Ophthalmological considerations in necrobiotic xanthogranuloma

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Atypical Necrobiotic Xanthogranuloma Associated with Epidermodysplasia Verruciformis

Necrobiotic xanthogranuloma is a rare, idiopathic, and chronic systemic granulomatous disorder that is usually associated with paraproteinemia of the immunoglobulin (Ig)G kappa (κ) type. It is clinically characterized by yellowish red-to-brown indurated often ulcerating nodules or plaques that usually involve the periorbital regions of the elderly. We report an atypical case of NXG affecting on...

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Physiopathology of necrobiotic xanthogranuloma with monoclonal gammopathy

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Interferon alpha-2a monotherapy for necrobiotic xanthogranuloma.

oids (5, 6). In our patient the titre of circulating anti-ICS antibodies was low, which might indicate a prolonged initial phase of PV before generalized development of bullae. The massive plasma cell in®ltrate seen in the lesional upper dermis may be a factor for the localization of the lesions. Another possibility is that an unknown mechanism prevents the generalization of PV, resulting in th...

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Necrobiotic xanthogranuloma is a rare disease characterized by indurated nodules and yellowish-red plaques in the dermis or subdermal tissues particularly in the periorbital region; the lesions are often ulcerated. This disease is frequently associated with hematological disorders such as monoclonal gammopathy and lymphoproliferative disorders. Its pathogenesis is unknown and the small number o...

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ژورنال

عنوان ژورنال: Clinical and Experimental Dermatology

سال: 2016

ISSN: 0307-6938

DOI: 10.1111/ced.12826